This year-end issue of EuroIntervention begins with a State-of-the-Art on transcatheter edge-to-edge repair in mitral regurgitation; and offers original research on the Watchman FLX vs Watchman 2.5; the predictors of underexpansion with the ACURATE neo platform; and valve-in-root TAVI after an aortic root operation; we also share three research correspondences on determining coronary microvascular dysfunction endotypes using invasive exercise testing; the 5-year results of SORT OUT X; and an analysis of RADIANCE-HTN TRIO on antihypertensive drugs; and more...